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A long weekend gives you the chance to fit in a run somewhere new, or to get an extra day of rest. If you can do a long run as part of a marathon training plan, great, but if not, enjoy the shorter runs and the change of the usual routine.
Use those three-day weekends, like Memorial Day, in the way that works for you. Just remember that if you're beach-bound, be prepared for hot weather, and bring the sweatproof sunblock!