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Orthotics can be a runner's best friend, but when they are worn out or improperly fitted, they can lead to injury.
Each week or so, give your orthotics a close look. They will show signs of wear, but look for excessive cracking in the front that could affect how they feel when your foot lands. Also check for wear on the heel. When the orthotics aren't supporting your feet properly, they aren't doing their job and need to be replaced or refurbished.
If you are running less than 50 miles a week, you can probably get about 2 years of mileage from your orthotics. If you are running more than that, visit your podiatrist about once a year to have your orthotics assessed and repaired if needed.